On the origin of the contractile force in skeletal muscle.
- 1 October 1979
- journal article
- research article
- Published by Proceedings of the National Academy of Sciences in Proceedings of the National Academy of Sciences
- Vol. 76 (10), 5066-5070
- https://doi.org/10.1073/pnas.76.10.5066
Abstract
Analysis of the early tension responses after abrupt step changes in the length of isometrically contracting [rabbit] skeletal muscle shows that the magnitude of the recovery tension (T2) and the time dependence of this process at various step displacements give a good correlation with the behavior expected for a helix-coil transition in the subfragment-2 (S-2) region of myosin. The instantaneous tension response (to T1) after the step change in length appears to have its origin in compliance within the coil region of S-2, which is formed through helix melting at the moment of force generation.This publication has 14 references indexed in Scilit:
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