Stabilization of Proteins Encapsulated in Cylindrical Poly(lactide-co-glycolide) Implants: Mechanism of Stabilization by Basic Additives
- 1 January 2000
- journal article
- Published by Springer Nature in Pharmaceutical Research
- Vol. 17 (3), 351-357
- https://doi.org/10.1023/a:1007513425337
Abstract
Purpose. A previous study from our group has shown that in theacidic microclimate of poly(lactide- co-glycolide) (PLGA) implants,encapsulated BSA forms insoluble noncovalent aggregates and...Keywords
This publication has 8 references indexed in Scilit:
- Stabilization of proteins encapsulated in injectable poly (lactide- co-glycolide)Nature Biotechnology, 2000
- The Acidic Microclimate in Poly(lactide-co-glycolide) Microspheres Stabilizes CamptothecinsPharmaceutical Research, 1999
- Development of a multiple-drug delivery implant for intraocular management of proliferative vitreoretinopathyJournal of Controlled Release, 1998
- Improving Stability and Release Kinetics of Microencapsulated Tetanus Toxoid by Co-Encapsulation of AdditivesPharmaceutical Research, 1998
- Effects of metal salts on poly(DL-lactide-co-glycolide) polymer hydrolysisJournal of Biomedical Materials Research, 1997
- Stabilization of 10-Hydroxycamptothecin in Poly(lactide-co-glycolide) Microsphere Delivery VehiclesPharmaceutical Research, 1997
- Stabilization of tetanus and diphtheria toxoids against moisture-induced aggregation.Proceedings of the National Academy of Sciences, 1995
- Solid‐Phase Aggregation of Proteins under Pharmaceutically Relevant ConditionsJournal of Pharmaceutical Sciences, 1994