The influence of purified somatomedins and insulin on foetal rat brain DNA synthesis in vitro
- 1 October 1985
- journal article
- Published by Wiley in Acta Physiologica Scandinavica
- Vol. 125 (2), 305-308
- https://doi.org/10.1111/j.1748-1716.1985.tb07720.x
Abstract
The two main forms of somatomedins, termed insulin-like growth factor I and II (IGF-I and IGF-II), have been isolated from human plasma. Pure IGF-I or IGF-II was incubated with foetal rat brain cells and found to be equipotent in stimulating the [3H]thymidine incorporation into DNA, despite the fact that IGF-I not is present during foetal life.Keywords
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