Humanized mice in translational biomedical research
Top Cited Papers
- 1 February 2007
- journal article
- review article
- Published by Springer Nature in Nature Reviews Immunology
- Vol. 7 (2), 118-130
- https://doi.org/10.1038/nri2017
Abstract
The culmination of decades of research on humanized mice is leading to advances in our understanding of human haematopoiesis, innate and adaptive immunity, autoimmunity, infectious diseases, cancer biology and regenerative medicine. In this Review, we discuss the development of these new generations of humanized mice, how they will facilitate translational research in several biomedical disciplines and approaches to overcome the remaining limitations of these models.Keywords
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