The microRNA-producing enzyme Dicer1 is essential for zebrafish development
- 5 October 2003
- journal article
- research article
- Published by Springer Nature in Nature Genetics
- Vol. 35 (3), 217-218
- https://doi.org/10.1038/ng1251
Abstract
MicroRNAs (miRNAs) are produced by the Dicer1 enzyme; the role of Dicer1 in vertebrate development is unknown. Here we report target-selected inactivation of the dicer1 gene in zebrafish. We observed an initial build-up of miRNA levels, produced by maternal Dicer1, in homozygous dicer1 mutants, but miRNA accumulation stopped after a few days. This resulted in developmental arrest around day 10. These results indicate that miRNA-producing Dicer1 is essential for vertebrate development.Keywords
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