Concentration of intravitreally injected triamcinolone acetonide in aqueous humour

Abstract

The unwanted proliferation of intraocular tissue such as vascular retinal cells in eyes with ischaemic retinopathies, subretinal neovascular tissue in eyes with exudative age related macular degeneration, and retinal pigment epithelium cells in the case of proliferative vitreoretinopathy, is one of the important problems still mostly unsolved in clinical ophthalmology. Since the early 1950s, corticosteroids have been used in ophthalmology to suppress intraocular inflammation by reducing inflammatory exudation and inhibiting proliferation of fibroblasts and formation of granulation tissue. They have been applied either topically as eyes drops, locally by subconjunctival, parabulbar or retrobulbar injections, or systemically as oral medications or intravenous or intramuscular injections. Machemer et al , based on clinical observations and pathogenic considerations, suggested the intravitreal application …