AN IMPROVED ASSAY METHOD FOR THYROTROPHIN USING DEPLETION OF I131FROM THE THYROID OF DAY-OLD CHICKS
- 1 February 1957
- journal article
- research article
- Published by The Endocrine Society in Endocrinology
- Vol. 60 (2), 225-238
- https://doi.org/10.1210/endo-60-2-225
Abstract
WAHLBERG (1) has summarized most of the literature on assay of thyrotrophin (TSH) in various animals. Recently, Piotrowski, Steelman and Koch (2) described an assay method for TSH based on depletion of the stable iodine from chick thyroids, and Gilliland and Strudwick (3) proposed an assay method based on depletion of I131 from the thyroids of baby chicks which were also treated with thyroxine to minimize endogenous secretion of TSH. Albert et al. (4) have shown that propylthiouracil (PTU) increased the thyroid weight response to TSH in baby chicks. More recently Halmi et al. (5) (6), and VanderLaan and Cap- Ian (7) have studied the effect of PTU on thyroid function in hypophysectomized rats and found PTU to accentuate the effect of TSH.Keywords
This publication has 6 references indexed in Scilit:
- ANALYSIS OF THE ACTION OF PROPYLTHIOURACIL ON THE PITUITARY-THYROID AXIS OF RATS1Endocrinology, 1954
- OBSERVATIONS ON A RELATIONSHIP BETWEEN TOTAL THYROID IODINE CONTENT AND THE IODIDE-CONCENTRATING MECHANISM OF THE THYROID GLAND OF THE RAT1Endocrinology, 1954
- THYROTROPIN ASSAY BASED ON THE DEPLETION OF IODINE IN CHICK THYROIDSEndocrinology, 1953
- A STUDY OF VARIOUS INFLUENCES ON THE IODIDE CONCENTRATING MECHANISM OF THE RAT THYROID1Endocrinology, 1953
- Activity of Citrovorum Factor it or the Chick.Experimental Biology and Medicine, 1952
- IN VIVO AUGMENTATION OF THYROTROPIC HORMONE AND PARTIAL REACTIVATION OF IODINATED (INACTIVE) THYROTROPIC HORMONE EXTRACT BY GOITROGENS1Endocrinology, 1947