TRP‐1 expression correlates with eumelanogenesis in human pigment cells in culture
- 2 August 1993
- journal article
- Published by Wiley in FEBS Letters
- Vol. 327 (3), 307-310
- https://doi.org/10.1016/0014-5793(93)81010-w
Abstract
We have investigated the relationship in human cultured normal and malignant melanocytes between the accumulation of mRNAs encoding tyrosinase and tyrosinase-related protein-1 (TRP-1), the activity of tyrosinase and the presence of melanin. Tyrosinase mRNA correlates with tyrosinase activity and with the presence of pheomelanin, eumelanin or both melanin types. In contrast TRP-1 mRNA is only detectable in cells containing eumelanin, which suggests a role for TRP-1 in the eumelanin synthesis pathway.Keywords
This publication has 21 references indexed in Scilit:
- After Dopachrome?Pigment Cell Research, 1991
- The melanoma antigen gp75 is the human homologue of the mouse b (brown) locus gene product.The Journal of Experimental Medicine, 1990
- Use of an Alpha-Melanocyte-Stimulating Hormone Analogue to Improve Alpha-Melanocyte-Stimulating Hormone Receptor Binding Assay in Human MelanomaPigment Cell Research, 1989
- Large-scale Cultivation of Human Melanocytes Using Collagen-coated Sephadex Beads (Cytodex 3)Journal of Investigative Dermatology, 1989
- Cloning and chromosomal location of human genes inducible by type I interferonSomatic Cell and Molecular Genetics, 1988
- A cDNA encoding tyrosinase-related protein maps to the brown locus in mouse.Proceedings of the National Academy of Sciences, 1988
- Assays for Mammalian Tyrosinase: A Comparative StudyPigment Cell Research, 1988
- Isolation and sequence of a cDNA clone for human tyrosinase that maps at the mouse c-albino locus.Proceedings of the National Academy of Sciences, 1987
- Pigmentation-Associated Glycoprotein of Human Melanomas and Melanocytes: Definition with a Mouse Monoclonal AntibodyJournal of Investigative Dermatology, 1985
- Microanalysis of eumelanin and pheomelanin in hair and melanomas by chemical degradation and liquid chromatographyAnalytical Biochemistry, 1985