Streptonigrin: Effect on the First Meiotic Metaphase of the Mouse Egg
- 28 July 1967
- journal article
- research article
- Published by American Association for the Advancement of Science (AAAS) in Science
- Vol. 157 (3787), 453-454
- https://doi.org/10.1126/science.157.3787.453
Abstract
Streptonigrin, an antibiotic and antitumor agent, alters the chromosomes of the mouse ovum during meiosis. Agglutination of bivalents or achromatic gaps and breaks occurred in the larger pairs both in vitro and in vivo. This newly detected cytogenetic effect suggests that such agents can gain access to developing mammalian ova and destroy the normal progress of meiosis.Keywords
This publication has 6 references indexed in Scilit:
- Effects of streptonigrin on nucleic acid metabolism of tissue culture cellsBiochimica et Biophysica Acta (BBA) - Nucleic Acids and Protein Synthesis, 1965
- THE KARYOTYPE OF THE MOUSE, WITH IDENTIFICATION OF A TRANSLOCATIONProceedings of the National Academy of Sciences, 1965
- A Method for Meiotic Preparations of Mammalian OvaCytogenetic and Genome Research, 1965
- The Specific Effects of Streptonigrin Activity on Human Chromosomes in CultureCytogenetic and Genome Research, 1963
- Meiosis in Ovarian Oocytes of Adult MammalsNature, 1962
- THE PERIOD OF DNA SYNTHESIS PRIOR TO MEIOSIS IN THE MOUSEThe Journal of cell biology, 1962