Enhancement of Ca2+-induced catecholamine release by the phorbol ester TPA in digitonin-permeabilized cultured bovine adrenal chromaffin cells
- 8 April 1985
- journal article
- research article
- Published by Wiley in FEBS Letters
- Vol. 183 (1), 107-110
- https://doi.org/10.1016/0014-5793(85)80964-9
Abstract
The phorbol ester, 4β-phorbol 12-myristate acetate (TPA), increased the extent of catecholamine release induced by Ca2+, without affecting the basal release response in digitonin-permeabilized chromaffin cells. This finding is consistent with the hypothesis that protein kinase C has a role to play in stimulus-secretion coupling in the bovine adrenal medullary chromaffin cell.Phorbol esterCathecholamineProtein kinase CChromaffinSecretionCa2+-induced releasKeywords
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