Interleukin-17: a mediator of inflammatory responses
- 1 March 2004
- journal article
- review article
- Published by Springer Nature in Cellular and Molecular Life Sciences
- Vol. 61 (5), 567-579
- https://doi.org/10.1007/s00018-003-3228-z
Abstract
Interleukin-17 (IL-17) is a prototype member of a new cytokine family with six species identified to date. IL-17 is secreted mainly by activated CD4+ and CD8+ T lymphocytes, while its receptor is distributed ubiquitously. IL-17 has been classified as a proinflammatory cytokine because of its ability to induce the expression of many mediators of inflammation, most strikingly those that are involved in the proliferation, maturation and chemotaxis of neutrophils. Increased levels of IL-17 have been associated with several conditions, including airway inflammation, rheumatoid arthritis, intraperitoneal abscesses and adhesions, inflammatory bowel disease, allograft rejection, psoriasis, cancer and multiple sclerosis. This review provides an overview of IL-17 activities, concentrating on those that lead to neutrophil recruitment.Keywords
This publication has 9 references indexed in Scilit:
- Effect of Rosiglitazone on the Risk of Myocardial Infarction and Death from Cardiovascular CausesNew England Journal of Medicine, 2007
- Reciprocal Relationships Between Insulin Resistance and Endothelial DysfunctionCirculation, 2006
- Novel Therapies Targeting Vascular EndotheliumEndothelium, 2006
- Treatment of medically uncontrolled coronary artery spasm in the normal coronary artery with coronary stenting.2002
- Coronary artery stent placement in patients with variant angina refractory to medical treatmentThe American Journal of Cardiology, 1999
- Long-term study of recurrent vasospastic angina using coronary angiograms during ergonovine provocation testsAmerican Heart Journal, 1992
- Percutaneous transluminal coronary angioplasty for the treatment of variant anginaJournal of the American College of Cardiology, 1985
- Coronary artery spasm: Demonstration, definition, diagnosis, and consequencesProgress in Cardiovascular Diseases, 1982
- Frequency of provoked coronary arterial spasm in 1089 consecutive patients undergoing coronary arteriography.Circulation, 1982