Influence of cyclosporin A on the respiration of isolated rat kidney mitochondria
- 8 April 1985
- journal article
- Published by Wiley in FEBS Letters
- Vol. 183 (1), 167-169
- https://doi.org/10.1016/0014-5793(85)80977-7
Abstract
In vitro exposure of isolated rat kidney mitochondria to cyclosporin A, a new immunosuppressive agent with serious nephrotoxic side-effects, leads to alterations of both succinate- and glutamate plus malate-supported respiration in a dose-related manner. ADP- and 2,4-dinitrophenol-stimulated respiration, respiratory control indices, and ADP/O ratios are decreased. The mitochondrial alterations are discussed as possible pathogenetic reasons of cyclosporin A nephrotoxicity.Keywords
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