Release of Corticotropin and Corticotropin-Releasing Factors from Rat Posterior Pituitary in vitro
- 1 January 1980
- journal article
- research article
- Published by S. Karger AG in Neuroendocrinology
- Vol. 30 (2), 110-112
- https://doi.org/10.1159/000122984
Abstract
Electrical stimulation of rat posterior lobes in vitro inhibited bioactive corticotropin (ACTH) release from the intermediate lobe and promoted the release of corticotropin-releasing factor(s) (CRF). Both effects were calcium dependent. Released posterior lobe CRF was inactivated by thioglycolate, and the CRF activity could be accounted for by vasopressin. Results suggest strongly that vasopressin is the predominant CRF released from neurohypophysial axons, and that intermediate lobe ACTH release is submitted to an inhibitory control.Keywords
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