THE EFFECT OF UROGASTRONE ON GASTRIC SECRETION IN ENTERECTOMIZED DOGS

Abstract

Because both urogastrone and entero-gastrone have similar physiological properties, i.e., gastric secretory inhibiting powers, the authors investigated the possibility that urogastrone acted through the liberation of enterogastrone. Inasmuch as enterogastrone is known to be secreted by the small intestine, they compared the gastric inhibitory power of urogastrone on total gastric pouch dogs with and without enterectomies. A comparison of the avg. responses to urogastrone inhibition of histamine induced gastric secretion showed a diminution of volume of 43.9% in controls and 68.6% in enterectomized animals, and a diminution in free acid output of 50% in controls and 80.6% in the enterectomized animals. The control series consisted of 8 expts. on 8 dogs and the exptl. series consisted of 12 expts. on 6 dogs. Urogastrone inhibition of gastric secretion is evidently independent of the presence of the small intestine and, therefore, its action is independent of that of enterogastrone.