A Study of Influenza Virus Vaccines by a Serum-Virus Neutralization Test and by Active Immunization
- 1 October 1947
- journal article
- research article
- Published by The American Association of Immunologists in The Journal of Immunology
- Vol. 57 (2), 195-202
- https://doi.org/10.4049/jimmunol.57.2.195
Abstract
It required approximately 63 to 125 times more influenza virus vaccine to immunize mice actively against infection caused by intranasal instillation of influenza viruses, PR 8 and Weiss (type A), than it did to stimulate circulating antibodies which neutralized the same quantity of virus, the tests being carried out in identical mice and at the same time. For the Lee strain (type B), five times more vaccine was necessary to produce active immunity comparable to the protection afforded to mice against influenza virus neutralized by immune serum elicited by a small amount of vaccine. The dilution of vaccine which actively immunized mice against influenza virus stimulated the production of immune serum of higher titer than did the dilutions of vaccine which did not actively protect the mice. A measurement of the smallest amount of vaccine which would produce immune serum in mice capable of protecting other mice against approximately 103LD50 doses of virus was utilized to determine the potency of influenza virus vaccines.Keywords
This publication has 8 references indexed in Scilit:
- QUANTITATIVE ASPECTS OF THE RED BLOOD CELL AGGLUTINATION TEST FOR INFLUENZA VIRUSThe Journal of Experimental Medicine, 1944
- THE EFFECT OF SUBCUTANEOUS VACCINATION WITH INFLUENZA VIRUS UPON THE VIRUS-INACTIVATING CAPACITY OF NASAL SECRETIONS1American Journal of Epidemiology, 1943
- The Correlation between Neutralizing Antibodies in Serum against Influenza Viruses and Susceptibility to Influenza in ManPublic Health Reports®, 1941
- NEUTRALIZATION OF EPIDEMIC INFLUENZA VIRUSThe Journal of Experimental Medicine, 1939
- QUANTITATIVE RELATIONSHIPS BETWEEN THE IMMUNIZING DOSE OF EPIDEMIC INFLUENZA VIRUS AND THE RESULTANT IMMUNITYThe Journal of Experimental Medicine, 1939
- STUDIES ON THE NASAL HISTOLOGY OF EPIDEMIC INFLUENZA VIRUS INFECTION IN THE FERRETThe Journal of Experimental Medicine, 1938
- THE OCCURRENCE OF NEUTRALIZING ANTIBODIES FOR HUMAN INFLUENZA VIRUS IN THE SERA OF PERSONS WITH VARIOUS HISTORIES OF INFLUENZA12American Journal of Epidemiology, 1936
- THE INCIDENCE OF NEUTRALIZING ANTIBODIES FOR HUMAN INFLUENZA VIRUS IN THE SERUM OF HUMAN INDIVIDUALS OF DIFFERENT AGESThe Journal of Experimental Medicine, 1936