Pitressin Tannate Therapy in Diabetes Insipidus

Abstract

A single intramusc. inj. of pitressin tannate in oil was very effective in controlling polydypsia and polyuria for a period of 24-48 hrs. in 3 patients with diabetes insipidus. The maximum therapeutic effect from any particular dose level was not attained for 48-96 hrs. For immediate control of symptoms a dose considerably larger than the maintenance dose was required. The continued adm. of excessive quantities of pitressin tannate in oil resulted in the appearance of signs and symptoms of water intoxication. In 2 patients the adm. of pitressin tannate in oil increased appreciably the amt. and duration of menstrual flow. Mineral balance studies indicated that the renal excretion of Na and Cl was reduced during periods of pitressin therapy.