THE MECHANISM OF GASTRIC MOTOR INHIBITION FROM INGESTED CARBOHYDRATES

Abstract

Carbohydrate solns., previously shown to inhibit hunger contractions when introduced into the normal empty stomach, in the present study produced the same effect when introduced into denervated and auto-transplanted gastric pouches (89 exps., 5 dogs), and into a stomach denervated by double vagotomy, double splanchnicotomy and celiac ganglionectomy (9 exps., 1 dog), indicating that a humoral factor is involved. Carbohydrate in contact with the upper intestine only (dogs with obstructed pylorus or with entire stomach made into a pouch) inhibited gastric mo-tility; carbohydrate in contact with gastric mucosa only (obstructed pylorus, entire stomach pouch or auto-transplanted pouch) did not. Apparently contact of carbohydrates exclusively with upper intestinal mucosa produces a gastric inhibitory humoral factor not identical with carbohydrate. An inhibitory nervous factor, if involved, is initiated from the same region.