Adverse effects on the brain in connection with isoflurane‐induced hypotensive anaesthesia
- 1 July 1989
- journal article
- research article
- Published by Wiley in Acta Anaesthesiologica Scandinavica
- Vol. 33 (5), 413-415
- https://doi.org/10.1111/j.1399-6576.1989.tb02935.x
Abstract
As a marker of brain cell injury, adenylate kinase (AK) was measured in cerebrospinal fluid (CSF) in 10 patients give anaesthesia with isoflurane-induced hypotension for corrective surgery of dentofacial deformities. Nine out of 10 patients displayed a marked increase in CSF-AK postoperatively compared with preoperative values. The postoperative mean value displayed a 400% increase compared to the corresponding preoperative value. This difference was statistically significant (P = 0.001). The rise in CSF-AK was most probably the result of an enhanced efflux of AK into CSF subsequent to a presumed hypoxic injury to brain cells.Keywords
This publication has 22 references indexed in Scilit:
- Cerebrospinal fluid markers of disturbed brain cell metabolism in patients with stroke and global cerebral ischemiaActa Neurologica Scandinavica, 2009
- Simultaneous correction of maxillary and mandibular dentofacial deformities without the use of postoperative intermaxillary fixation. A clinical and cephalometric studyInternational Journal of Oral & Maxillofacial Surgery, 1988
- Orthognathic Surgery with no Postoperative Intermaxillary FixationScandinavian Journal of Plastic and Reconstructive Surgery, 1987
- Perspectives of Adenylate Kinase Activity and Glutathione Concentration in Cerebrospinal Fluid of Patients with Ischemic and Neoplastic Brain LesionsEuropean Neurology, 1982
- Ischemic edema in stroke. A parallel study with computed tomography and cerebrospinal fluid markers of disturbed brain cell metabolism.Stroke, 1981
- The Effect of Hypercapnic Acidosis upon the Energy Metabolism of the Brain in Arterial Hypotension Caused by BleedingActa Physiologica Scandinavica, 1973
- EFFECTS OF INCREASED CEREBROSPINAL FLUID PRESSURE UPON ADENINE NUCLEOTIDES AND UPON LACTATE AND PYRUVATE IN RAT BRAIN TISSUEActa Neurologica Scandinavica, 1970
- ASSESSMENT OF CEREBRAL EFFECTS OF DELIBERATE HYPOTENSION BY PSYCHOLOGICAL MEASUREMENTSThe Lancet, 1964
- AN ANAESTHETIC TECHNIQUE FOR PROSTATECTOMYThe Lancet, 1959
- INDUCED HYPOTENSION DURING ANESTHESIA AND SURGERYAnesthesiology, 1955