Rationale and Design of a Secondary Prevention Trial of Antibiotic Use in Patients after Myocardial Infarction: The WIZARD (Weekly Intervention with Zithromax [Azithromycin] for Atherosclerosis and Its Related Disorders) Trial
- 1 June 2000
- journal article
- clinical trial
- Published by Oxford University Press (OUP) in The Journal of Infectious Diseases
- Vol. 181 (s3), S572-S578
- https://doi.org/10.1086/315634
Abstract
Mounting evidence supports the contention that atherosclerosis is an inflammatory disease. Recently a possible role for infectious microorganisms has gathered attention. Chlamydia pneumoniae is one possible pathogen. If C. pneumoniae is a target organism, antibiotics with antichlamydial activity may be able to ameliorate plaque instability. The WIZARD trial is a secondary prevention study that is assessing the impact of a 3-month course of azithromycin compared with placebo on the progression of clinical coronary heart disease. The study will enroll 3300 patients who have had a prior myocardial infarction and who have a C. pneumoniae IgG titer of ⩾ 1:16. The primary end point is a composite of time to either recurrent myocardial infarction, death, a revascularization procedure, or hospitalization for angina. This study is the first of a series of adequately powered clinical trials that will attempt to bridge insights from preclinical investigations to interventions applicable to patient care.Keywords
This publication has 22 references indexed in Scilit:
- Atherosclerosis — An Inflammatory DiseaseNew England Journal of Medicine, 1999
- Prevention of Cardiovascular Events and Death with Pravastatin in Patients with Coronary Heart Disease and a Broad Range of Initial Cholesterol LevelsNew England Journal of Medicine, 1998
- Inflammation, Aspirin, and the Risk of Cardiovascular Disease in Apparently Healthy MenNew England Journal of Medicine, 1997
- Prophylaxis against DisseminatedMycobacterium aviumComplex with Weekly Azithromycin, Daily Rifabutin, or BothNew England Journal of Medicine, 1996
- Prevention of Coronary Heart Disease with Pravastatin in Men with HypercholesterolemiaNew England Journal of Medicine, 1995
- Inhalation of levomepromazine in severe acute asthmaThe Lancet, 1994
- Seroepidemiology of Chlamydia pneumoniae TWAR Infection in Seattle Families, 1966-1979The Journal of Infectious Diseases, 1992
- The in-vitro antibiotic susceptibility of Chlamydia pneumoniaeJournal of Antimicrobial Chemotherapy, 1990
- SEROLOGICAL EVIDENCE OF AN ASSOCIATION OF A NOVEL CHLAMYDIA, TWAR, WITH CHRONIC CORONARY HEART DISEASE AND ACUTE MYOCARDIAL INFARCTIONThe Lancet, 1988
- Discrete Sequential Boundaries for Clinical TrialsBiometrika, 1983