ROLE OF T-LYMPHOCYTES IN COLLAGEN-II INDUCED ARTHRITIS IN RATS
- 1 January 1983
- journal article
- research article
- Vol. 51 (1), 117-125
Abstract
Functional T cells were needed for the development of arthritis since none of the 14 nude rats injected with collagen type II developed arthritis, while 11 of 14 of their normal counterparts did. With the help of antibodies specific for Ia antigens and different T cell subsets in the rats, an immunohistochemical method was used to demonstrate that T cells, predominantly of the helper type, and anti-Ia reactive non-T cells were abundant in the arthritic synovial tissue.This publication has 27 references indexed in Scilit:
- RHEUMATOID ARTHRITIS: A DISEASE OF T-LYMPHOCYTE/MACROPHAGE IMMUNOREGULATIONThe Lancet, 1981
- Type II collagen-induced arthritis in mice. I. Major histocompatibility complex (I region) linkage and antibody correlates.The Journal of Experimental Medicine, 1981
- Appearance of Anti‐HLA‐DR‐Reactive Cells in Normal and Rheumatoid Synovial TissueScandinavian Journal of Immunology, 1981
- Autoimmunity to collagen in adjuvant arthritis of rats.JCI Insight, 1980
- Two subsets of rat T lymphocytes defined with monoclonal antibodiesEuropean Journal of Immunology, 1980
- Immunisation against heterologous type II collagen induces arthritis in miceNature, 1980
- Passive Transfer by Cells of Type II Collagen-Induced Arthritis in RatsJCI Insight, 1978
- Identification of H‐2 and Ia‐Antigen Analogues in Several Species by Immunological Crossreactions of XenoantiseraScandinavian Journal of Immunology, 1978
- Analysis of cell surfaces by xenogeneic myeloma-hybrid antibodies: Differentiation antigens of rat lymphocytesCell, 1977
- THYMUS INDEPENDENCE OF A COLLAGEN-LIKE SYNTHETIC POLYPEPTIDE AND OF COLLAGEN, AND THE NEED FOR THYMUS AND BONE MARROW-CELL COOPERATION IN THE IMMUNE RESPONSE TO GELATINThe Journal of Experimental Medicine, 1974