Pancuronium, d-Tubocurarine, and Epinephrine-iriduced Arrhythmias during Halothane Anesthesia in Dogs

Abstract

The effects of pancuronium, 14-200 .mu.g/kg, and d-tubocurarine, 100-400 .mu.g/kg, on epinephrine-induced arrhythmias (premature ventricular contractions) were studied in dogs anesthetized with halothane, 1.4 minimum anesthetic concentration. Neither muscle relaxant significantly affected the arrhythmogenic epinephrine dose. The usual guidelines for the administration of epinephrine during halothane anesthesia are not affected by concomitant administration of the 2 nondepolarizing muscle relaxants studied.