The clinical picture and autopsy findings of a fatal case of veno-occlusive disease of the liver (V.O.D.) occurring in a 10 month old Jamaican infant is reported. Points of similarity between V.O.D. and Budd-Chiari's syndrome, senecio poisoning and Indian infantile cirrhosis are noted. The possible eiology of V.O.D. is considered. It is postulated that V.O.D. is an important cause of cirrhosis of the liver in Jamaican children.