Residual Calcium Ions Depress Activation of Calcium-Dependent Current
- 14 May 1982
- journal article
- research article
- Published by American Association for the Advancement of Science (AAAS) in Science
- Vol. 216 (4547), 730-733
- https://doi.org/10.1126/science.6281880
Abstract
Calcium ions enter and accumulate during depolarization of some cells, activating a potassium current, IK(Ca), that depends on the cytoplasmic concentration of calcium ions, [Ca]i. However, elevation of [Ca]i can depress IK(Ca) elicited by a subsequent membrane depolarization. The depression of IK(Ca) is ascribed here to a [Ca]i-mediated inactivation of the voltage-gated calcium conductance, which causes a net reduction in calcium ions available for the activation of IK(Ca). This suggests that other processes dependent on gated calcium entry may also be depressed by small background elevations in cytosolic free calcium ions.This publication has 31 references indexed in Scilit:
- Calcium Dependence of the Inactivation of Calcium Currents in Skeletal Muscle Fibers of an InsectScience, 1981
- Ca-dependent K channels with large unitary conductance in chromaffin cell membranesNature, 1981
- Synaptic Excitation May Activate a Calcium-Dependent Potassium Conductance in Hippocampal Pyramidal CellsScience, 1981
- Calcium ChannelAnnual Review of Neuroscience, 1981
- Calcium Entry Leads to Inactivation of Calcium Channel in ParameciumScience, 1978
- CALCIUM-DEPENDENT POTASSIUM ACTIVATION IN NERVOUS TISSUESAnnual Review of Biophysics and Bioengineering, 1978
- Potassium Activation Associated with Intraneuronal Free CalciumScience, 1978
- Calcium-Dependent Depression of a Late Outward Current in Snail NeuronsScience, 1977
- Calcium-activated conductance in skate electroreceptors: voltage clamp experiments.The Journal of general physiology, 1977
- Two Fast Transient Current Components during Voltage Clamp on Snail NeuronsThe Journal of general physiology, 1971