Incorporation of glucocerebrosidase into Gaucher's disease monocytes in vitro.
- 1 January 1979
- journal article
- research article
- Published by Proceedings of the National Academy of Sciences in Proceedings of the National Academy of Sciences
- Vol. 76 (1), 473-475
- https://doi.org/10.1073/pnas.76.1.473
Abstract
Several carriers were evaluated for use in the delivery of exogenous glucocerebrosidase to monocytes from Gaucher''s disease patients. Only .gamma.-globulin-coated, resealed erythrocytes proved to be an effective vehicle for enzyme delivery. Glucocerebrosidase added in this manner normalized intracellular enzyme levels for at least 18 h. In this model system for the study of enzyme replacement therapy, soluble enzyme, enzyme in uncoated resealed erythrocytes and enzyme incorporated into liposomes were ineffective.This publication has 19 references indexed in Scilit:
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