Histological Characteristics of Prostatic Biopsies after 125 Iodine Implantation

Abstract
There were 39 prostatic needle biopsies obtained from 33 patients with carcinoma of the prostate 1-3 yr after definitive treatment with interstitial implantation using 125iodine radioactive sources. Of these biopsies, 57% obtained at 12-18 mo. and 73% obtained at 19-36 mo. after implantation were negative for malignancy. All biopsies revealed histologic evidence of significant radiation injury. Neither the presence or absence of malignancy on biopsy nor the degree of radiation injury could be related to the initial stage and grade of the prostatic neoplasm.