CHRONIC RELAPSING EXPERIMENTAL ALLERGIC ENCEPHALOMYELITIS IN STRAIN-13 GUINEA-PIGS - PRESENCE OF MYELIN BASIC-PROTEIN IN THE LOCAL TISSUE LONG AFTER THE IMMUNIZATION
- 1 January 1982
- journal article
- research article
- Vol. 52 (3), 131-137
Abstract
To understand the induction mechanism of chronic form of EAE [experimental allergic encephalomyelitis] the immunized sites of EAE animals were studied with immunocytochemical techniques. There were numerous vacuoles associated with inflammatory reactions in the s.c. tissue of immunized feet. Immunocytochemical staining with antiserum to myelin basic protein (MBP) disclosed remaining of MBP in and around the vacuoles. The MBP remained more in early stage and less in chronic stage; it remained even on 326th day of postimmunization. A possible role of the remained antigen in chronic EAE was discussed.This publication has 3 references indexed in Scilit:
- Myelin basic protein serum factor. An endogenous neuroantigen influencing development of experimental allergic encephalomyelitis in Lewis rats.The Journal of Experimental Medicine, 1978
- Myelin basic protein demonstrated immunocytochemically in oligodendroglia prior to myelin sheath formation.Proceedings of the National Academy of Sciences, 1978
- Antibodies to Bradykinin and Angiotensin: A Use of Carbodiimides in ImmunologyScience, 1964