RESPIRATION AT HIGH-ALTITUDES, PHOSPHATE-PROTEIN INTERACTION - SEQUENCE OF HEMOGLOBINS FROM GUINEA-PIG AND DROMEDARY

Abstract

The sequence of the main Hb component of the guinea pig (C. aperea f. porcellus, Caviidae) and that of the Hb of the dromedary (C. dromedarius, Camelidae) was given. The sequence was obtained automatically by the sequenator using the quadrol and the propyne program. The sequence of the .alpha.- and .beta.-chains of the guinea pig was compared with that of the human Hb; the sequence of the dromedary in comparison to the llama shows in the .alpha.-chains 5 amino acid exchanges, in the .beta.-chains there are only 2 exchanges in .beta.2 and .beta.76. In dromedary, .beta.2 was the P2-glycerate contact histidine. This sustains the interpretation of the high altitude respiration of the llama as mutation .beta.2His.fwdarw.Asn.