Studies on orally active cephalosporin esters.
- 1 January 1987
- journal article
- research article
- Published by Japan Antibiotics Research Association in The Journal of Antibiotics
- Vol. 40 (3), 370-384
- https://doi.org/10.7164/antibiotics.40.370
Abstract
The synthesis and the biological properties of orally active cephalosporin esters are described. 3-Methoxymethyl cephem derivatives having a 2-(2-aminothiazol-4-yl)-(Z)-2-methoxyiminoacetamide function at C-7 (1) showed good activity against a wide variety of bacteria including some .beta.-lactamase producing species. The prodrug type esters of 1 exhibited a good urinary recovery after oral administration to mice and 1-(isopropoxycarbonyloxy)ethyl ester (2a, CS-807) has been pre-clinically tested as an orally active cephem prodrug.This publication has 3 references indexed in Scilit:
- Studles on β-Lactam Antibiotics for Medicinal Purpose. XVIIIYAKUGAKU ZASSHI, 1986
- Studies on .BETA.-lactam antibiotics. IX. Synthesis and biological activity of a new orally active cephalosporin, cefixime (FK027).The Journal of Antibiotics, 1985
- Studies on prodrugs. II. Preparation and characterization of (5-substituted 2-Oxo-1,3-dioxolen-4-yl)methyl esters of ampicillin.CHEMICAL & PHARMACEUTICAL BULLETIN, 1984