Dendritic Spine "Dysgenesis" and Mental Retardation
- 20 December 1974
- journal article
- other
- Published by American Association for the Advancement of Science (AAAS) in Science
- Vol. 186 (4169), 1126-1128
- https://doi.org/10.1126/science.186.4169.1126
Abstract
Golgi studies reveal abnormally long, thin spines and the absence of short, thick spines on dendrites of cortical neurons in retarded children with normal karyotypes. The degree of dendritic spine loss and abnormality appears to be related to age and the severity of developmental retardation. Dendritic spine "dysgenesis" is a common feature of the microstructural pathology that occurs in profound mental retardation of unknown etiology.Keywords
This publication has 11 references indexed in Scilit:
- Dendritic development in neocortex of children with mental defect and infantile spasmsNeurology, 1974
- Structural organization of the cerebral cortex (motor area) in human chromosomal aberrations. A golgi study. I. D1 (13–15) trisomy, patau syndromeBrain Research, 1974
- Synaptic patterns in the visual cortex of the cat and monkey. Electron microscopy of Golgi PreparationsJournal of Comparative Neurology, 1973
- Organization of neurons in the visual cortex, area 17, of the monkey (Macaca mulatta)Journal of Comparative Neurology, 1973
- Structural abnormalities of the cerebral cortex in human chromosomal aberrations: a Golgi studyBrain Research, 1972
- The small pyramidal neuron of the rat cerebral cortex. The perikaryon, dendrites and spinesJournal of Anatomy, 1970
- The termination of callosal fibers in the paravisual cortex of the ratBrain Research, 1970
- Synaptic patterns on different cell types in the different laminae of the cat visual cortex. An electron microscope studyBrain Research, 1968
- Synaptic loci on visual cortical neurons of the rabbit: The specific afferent radiationExperimental Neurology, 1967
- ANALYSIS OF AXODENDRITIC SYNAPTIC ORGANIZATIONS IN IMMATURE CEREBRAL CORTEX*Annals of the New York Academy of Sciences, 1961