ENHANCEMENT OF ACTINOMYCIN D-DIAMMINEDICHLOROPLATINUM(II)-INDUCED AND CIS-DIAMMINEDICHLOROPLATINUM(II)-INDUCED KILLING OF HUMAN-FIBROBLASTS BY HUMAN BETA-INTERFERON
- 1 January 1983
- journal article
- research article
- Vol. 43 (11), 5484-5488
Abstract
When normal or transformed human fibroblasts are incubated with actinomycin D, RNA synthesis is irreversibly inhibited, and the treated cells eventually die. This cell-killing effect of actinomycin D is significantly ehnanced by pretreating the cells with human interferon. This effect of interferon is species-specific and appears to be under the control of gene(s) located on human chromosome 21. Enhancement of cell killing effect of cis-platinum by interferon pretreatment is also observed.This publication has 10 references indexed in Scilit:
- Tunicamycin Enhances the Antiviral and Anticellular Activity of InterferonScience, 1983
- Tumor Suppression with a Combination of α-Difluoromethyl Ornithine and InterferonScience, 1983
- Effect of treatment with interferon and cyclophosphamide on the growth of a spontaneous liposarcoma in ratsInternational Journal of Cancer, 1983
- MODULATION OF 5-FLUOROURACIL-INDUCED TOXICITY IN MICE WITH INTERFERON OR WITH THE INTERFERON INDUCER, POLYINOSINIC-POLYCYTIDYLIC ACID1983
- Antitumor Effect of Combined Interferon and Hyperthermia in MiceExperimental Biology and Medicine, 1982
- Radioimmunoassay for human beta interferonInfection and Immunity, 1981
- Combined interferon-antimetabolite therapy of murine L1210 leukemiaCancer, 1981
- Human fibroblastoid interferon: immunosorbent column chromatography and N-terminal amino acid sequenceBiochemistry, 1980
- The combined effect of interferon and methotrexate on human osteosarcoma and lymphoma cell linesCancer Letters, 1980
- Efficacy of combined interferon cyclophosphamide therapy after diagnosis of lymphoma in AKR miceEuropean Journal of Cancer (1965), 1978