Renal Regulation of Serum α-Lipoproteins

Abstract

STUDIES of families have shown that absence of serum α-lipoprotein may be genetically determined.¹ The importance of female sex hormones in its regulation was suggested when higher levels were observed in females than in males,² and when increased concentrations were found in men treated with estrogen.³ When low concentrations were observed in nephrotic patients⁴ it was suggested the kidneys might participate in determining the level.The present study indicates a relation between kidney and α-lipoprotein levels – that is, high-density lipoproteins with electrophoretic mobility of α1-globulin. Low levels of serum α-lipoprotein were found in patients with terminal uremia, or those . . .