Sterols in Brain and Liver of Young Rats Fed 20,25-Diaza-Cholesterol

Abstract

Summary Feeding 0.03% diazasterol in essentially cholesterol-free diets to weanling rats for 3 or 6 weeks caused a large concentration of desmosterol in the brain and liver sterols. Studies using C¹⁴ showed that small amounts of acetate and glucose were incorporated into brain sterol of both control and inhibitor-fed rats and a mode by which this incorporation may account for the rate of desmosterol accumulation is postulated.