THE TRANSPLANTATION OF ALLOGENEIC HAEMOPOIETIC TISSUE IN ADULT ANAEMIC MICE OF THE W-SERIES PREVIOUSLY MADE IMMUNOLOGICALLY TOLERANT

Abstract

SUMMARY Anaemic mice (genotype W^VW^V) were injected with allogeneic CBA lymphoid cells within the 1st day of life. When adult, they were challenged with a CBA skin graft, and the subsequent tolerant (accepted the skin graft), nontolerant (rejected the graft) and control (untreated) mice were injected with CBA haemopoietic tissue. The control mice showed no change in their erythrocyte count (RBC) during the next 100 days, while the tolerant mice showed a marked increase after 10 days and had a normal RBC by 50 days. Some of the nontolerant mice showed no change in their RBC, while others had a delayed increase in RBC. This suggests that the conditions which permit the survival of a haemopoietic graft are less stringent than those needed for the persistence of a skin graft.