Rabies Virus Infection Selectively Impairs Membrane Receptor Functions in Neuronal Model Cells
- 1 March 1979
- journal article
- research article
- Published by Microbiology Society in Journal of General Virology
- Vol. 42 (3), 627-632
- https://doi.org/10.1099/0022-1317-42-3-627
Abstract
A persistent infection with rabies virus (HEP-Flury) was established in the CNS[central nervous system]-derived [mouse neuroblastoma .times. rat glioma] hybrid cell line 108 CC15 which possesses specific membrane receptors for prostaglandins [PGE], catecholamines and acetylcholine. A differential virus influence on the specific receptor response to PGE, isoproterenol and acetylcholine as indicated by typical changes of the intracellular cyclic[c]AMP levels is reported. As the adenylate cyclase activity was unchanged in infected cells in vitro, a selective virus influence on specific receptors themselves or their coupling to the cAMP synthesizing system must be considered.This publication has 6 references indexed in Scilit:
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