A brief review of the literature concerning cytomegalic inclusion disease has been presented. Representative cases from the files of The Cincinnati Children's and the Cincinnati General Hospitals have been included to demonstrate the variety of clinical pictures which may be associated with the presence of visceral inclusions of the human salivary gland virus. Analysis of the cases reviewed leads to the conclusion that there are three general syndromes associated with this disease. The clinical features of the first resemble those of severe erythroblastosis fetalis on neonatal sepsis. The second syndrome is not so clearly defined, but is most commonly characterized by chronic respiratory disease, and gastrointestinal disorders in infants beyond the newborn period. The third group consists of patients in whom the visceral inclusions probably are the result of a virus infection or dissemination due to debility from a variety of diseases.