Imidazole and Polyene Activity Against Chloroquine-Resistant Plasmodium falciparum

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Abstract
Two imidazoles (ketoconazole and miconazole) and a polyene (amphotericin B) were active against both chloroquine-susceptible and chloroquine-resistant Plasmodium falciparum in vitro. The efficacy of these agents at clinically achievable concentrations suggests that they may also be effective against multidrug-resistant P. falciparum in vivo. The antimalarial activity of imidazoles (which inhibitsterolsynthesis in fungi) suggests that the malaria parasitemaysynthesize sterols and mayprovide a valuable probe to study the lipid metabolism of plasmodia.