THE DEVELOPMENT OF RESISTANCE TO 6-MERCAPTOPURINE IN A SUBLINE OF THE EHRLICH ASCITES CARCINOMA
- 1 October 1960
- journal article
- research article
- Published by Canadian Science Publishing in Canadian Journal of Biochemistry and Physiology
- Vol. 38 (10), 1117-1127
- https://doi.org/10.1139/o60-138
Abstract
A subline of the Ehrlich ascites carcinoma has been developed which grows under 6-mercaptopurine (6-MP) therapy at approximately five times the rate of the parent line. Cells of the resistant subline were almost completely incapable of converting 6-MP to 6-MP nucleotide in contrast to those of the parent tumor line. A relationship between resistance to 6-MP and the capacity of the tumor cells to synthesize 6-MP nucleotide was indicated by a long-term study of these properties in branches of the resistant tumor subline which were maintained with and without exposure to 6-MP.Keywords
This publication has 10 references indexed in Scilit:
- Studies on the Mode of Action of 6-Mercaptopurine and Its Ribonucleoside on Mammalian Cells in CultureJournal of Biological Chemistry, 1959
- Decreased ribonucleotide pyrophosphorylase activity of Streptococcus faecalis and L1210 leukaemia resistant to purine antagonistsBiochemical Pharmacology, 1959
- Possible Enzymic Mechanism for the Development of Resistance against Fluorouracil in Ascites TumoursNature, 1959
- THE FORMATION OF 6-MERCAPTOPURINE RIBOSIDE PHOSPHATE IN ASCITES TUMOR CELLSCanadian Journal of Biochemistry and Physiology, 1959
- ENZYMATIC SYNTHESIS OF 5'-PHOSPHATE NUCLEOTIDES OF PURINE ANALOGUESJournal of Biological Chemistry, 1958
- METABOLIC EFFECTS OF 6-THIOGUANINE .1. STUDIES ON THIOGUANINE-RESISTANT AND THIOGUANINE-SENSITIVE EHRLICH ASCITES CELLS1958
- METABOLISM OF 6-THIOGUANINE IN NORMAL AND NEOPLASTIC TISSUES1958
- METABOLISM OF 2,6-DIAMINOPURINE: CONVERSION TO 5'-PHOSPHORIBOSYL-2-METHYLAMINO-6-AMINOPURINE BY ENZYMES OF ESCHERICHIA COLIJournal of Biological Chemistry, 1957
- A STUDY OF THE METABOLISM OF PURINE RIBOSIDEJournal of Biological Chemistry, 1956
- EFFECTS OF 6‐MERCAPTOPURINE ON EXPERIMENTAL TUMORSAnnals of the New York Academy of Sciences, 1954