CLL and Diffuse Histiocytic Lymphoma in One Patient: Clonal Proliferation of Two Different B Cells
- 1 January 1978
- journal article
- research article
- Published by Wiley in Scandinavian Journal of Haematology
- Vol. 20 (1), 29-36
- https://doi.org/10.1111/j.1600-0609.1978.tb01551.x
Abstract
A case report is presented of a 77 yr old woman suffering from a composite lymphoma, known as Richter''s syndrome, consisting of chronic lymphocytic leukemia (CLL) and diffuse histiocytic lymphoma. Light-microscopic investigation revealed the presence of CLL cells in the blood and bone marrow and a combination of CLL cells and large immunoblastic cells in the lymph node. Immunological investigation showed that both malignant cell types were B [bone marrow-derived] cells. The CLL cells carried a monoclonal surface immunoglobulin (S-Ig) .mu..lambda., and the immunoblastic cells had a monoclonal S-Ig .mu..kappa.. Both clonal lymphoproliferative diseases were probably derived from different tumor stem cells.Keywords
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