In Vitro Sulfate Fixation by Granulation Tissue and Injured Muscle Tissue from Healing Wounds.

Abstract

The author has shown (Cancer, July 1950) that embryonic chick tissues maintained in vitro utilize inorganic sulfate, converting it to tissue insoluble (or fixed) organic sulfate. Normal adult muscle tissue exhibits no significant affinity for sulfate in vivo or in vitro. Granulation tissue and injured muscle tissue from healing wounds (3 or 4 days after wounding) in young and adult chickens exhibit high affinities for sulfate ions, being in this respect similar to muscle tissue from developing embryos. It is suggested that sulfate ions are utilized in the synthesis of connective tissue substance, and that anabolic sulfate metabolism of the tissue fibroblasts may be a limiting factor in wound healing.