Functional recovery of cortical neurons as related to degree and duration of ischemia
- 1 September 1983
- journal article
- research article
- Published by Wiley in Annals of Neurology
- Vol. 14 (3), 294-301
- https://doi.org/10.1002/ana.410140307
Abstract
Imultaneous recordings of spontaneous single cell activity and local cerebral blood flow were obtained from 72 cortical neurons and adjacent brain in 54 cats before, during, and after ischemia induced by reversible occulsion of the middle cerebral artery. In most cells spontaneous electrical activity ceased at flow values of about 0.18 ml/gmm/in (range, 0.06 to 0.22 ml/gm/min). No signal was obtained from 28 neurons during reperfusion following ischemia of varying degree and duration. Overall, neurons exposed to a residual flow of 0.14 ml/gm/min or less for more than 45 minutes had a poorer prognosis compared to any other combination of degree and duration of ischemia. A discriminant curve was estimated to define the border line between recovering and nonrecovering cells. Regions showing irreversible neuronal failure contained selective neuronal necrosis or areas of infarction by histological examination. Reperfusion restored neuronal function in 44 cells. In this group of neurons, there was a joint interaction of duration of ischemia, ischemic residual flow, and recovery time: cells exposed to moderate ischemia (0.09 to 0.22 ml/gm/min) for up to 20 minutes recovered rapidly; most neurons subjected either to extreme ischemia (less than 0.09 ml/gm/min) of short duration (less than 20 minutes) or to moderate ischemia (0.09 to 0.22 ml/gm/min) for longer periods (20 to 141 minutes) required from 19 to 50 minutes for recovery. A few resistant neurons tolerated less than 0.09 ml/gm/min for more than 20 minutes. Cell survival and functional recovery following ischemia depend not only on separate effects of residual flow and duration of ischemia but on their combined influence. Selective vulnerability forms the natural basis of scattered cell survival.This publication has 26 references indexed in Scilit:
- Differential regional vulnerability in transient focal cerebral ischemia.Stroke, 1982
- Temporal profile of neuronal damage in a model of transient forebrain ischemiaAnnals of Neurology, 1982
- Comparison between hydrogen clearance and microsphere technique for rCBF measurement.Stroke, 1981
- Correlation between rCBF and histological changes following temporary middle cerebral artery occlusion.Stroke, 1980
- Implanted device for middle cerebral artery occlusion in conscious cats.Stroke, 1977
- Cation activities in reversible ischemia of the cat brain.Stroke, 1977
- Cortical evoked potential and extracellular K+ and H+ at critical levels of brain ischemia.Stroke, 1977
- Immediate Effects of Cerebral Ischemia: Evolution and Resolution of Neurological Deficits After Experimental Occlusion of One Middle Cerebral Artery in Conscious CatsStroke, 1975
- The Distribution and Density of Reduced Cerebral Blood Flow Following Acute Middle Cerebral Artery Occlusion: An Experimental Study by the Technique of Hydrogen Clearance in BaboonsStroke, 1974
- Correlation of Continuous Electroencephalograms With Cerebral Blood Flow Measurements During Carotid EndarterectomyStroke, 1973