Plasma Levels of Trazodone: Methodology and Applications
- 1 January 1984
- journal article
- research article
- Published by S. Karger AG in Pharmacology
- Vol. 28 (1), 42-46
- https://doi.org/10.1159/000137941
Abstract
A sensitive (to 5.0 ng/ml) and specific method for analysis of the antidepressant trazodone is described. The method utilizes gas-liquid chromatography with nitrogen-phosphorus detection. Applicability of the method is demonstrated by (1) a pharmacokinetic study in a normal volunteer who received 50 mg trazodone orally and (2) steady-state plasma level determinations of 2 patients receiving trazodone in the treatment of depression.Keywords
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