Successuful treatment of paramyotonia congenita (Eulenburg): muscle stiffness and weakness prevented by tocainide.
- 1 March 1980
- journal article
- research article
- Published by BMJ in Journal of Neurology, Neurosurgery & Psychiatry
- Vol. 43 (3), 268-271
- https://doi.org/10.1136/jnnp.43.3.268
Abstract
Recent studies have shown that the Na conductance of the sarcolemma is disturbed in paramyotonia. Tocainide is a new antiarrhythmic agent which seems to reduce effectively Na conductance. Patients [8] with paramyotonia were treated with tocainide, whereby the paramyotonic stiffness and weakness brought about by cooling could be prevented.This publication has 12 references indexed in Scilit:
- Influence of temperature on isometric contraction and passive muscular tension in paramyotonia congenita (Eulenburg)Zeitschrift für Neurologie, 1979
- Effects of tocainide on left ventricular performance at rest and during acute alterations in heart rate and systemic arterial pressure. An echocardiographic study.Heart, 1979
- Effects of tocainide on normal and myotonic mammalian skeletal muscle.1979
- Electrocardiographic and hemodynamic effects of tocainide (W-36095) in manEuropean Journal of Clinical Pharmacology, 1978
- Sodium currents in mammalian muscleThe Journal of Physiology, 1977
- Myotonia not aggravated by coolingZeitschrift für Neurologie, 1977
- Clinical efficacy and pharmacokinetics of a new orally effective antiarrhythmic, tocainide.Circulation, 1976
- Spin label study of erythrocyte membrane fluidity in myotonic and Duchenne muscular dystrophy and congenital myotoniaNature, 1976
- Muscle membrane potentials in episodic adynamiaElectroencephalography and Clinical Neurophysiology, 1963
- Paresis and hyperexcitability in adynamia episodica hereditariaNeurology, 1958