Brief Communication: Oncogenesis by Marek's Disease Herpesvirus in Chickens Lacking Expression of Endogenous (gs, Chick Helper Factor, Rous-Associated Virus-O) and Exogenous Avian RNA Tumor Viruses

Abstract

Chickens free of exogenous avian leukosis virus (ALV) infection, replicating endogenous ALV (Rous-associated virus-O), gs antigen, and chick helper factor were fully susceptible to induction of Marek's disease (MD) by ALV-free MD viruses. Dual infection with Rous-associated virus-2 and MD virus did not significantly after the character of the MD lesion. Thus exogenous ALV infectIon was not requisite for MD virus-induced oncogenesis. Although participation of endogenous RNA tumor virus genes in MD lesion induction could not be excluded, expression of such genes in MD tumors as gs antigen was not established