T-cell receptor V T? genes in natural populations of mice
- 1 January 1988
- journal article
- conference paper
- Published by Springer Nature in Immunogenetics
- Vol. 27 (1), 51-56
- https://doi.org/10.1007/bf00404444
Abstract
The composition of 15 V Tβ gene subfamilies has been examined by Southern hybridization among a broad spectrum of colony bred rat and mouse species extending phylogenetically from Rattus to Mus musculus domesticus. Most mouse species contain a similar content of V Tβ genes as determined by the number of hybridizing restriction fragment (RF) bands. Furthermore, the extent of restriction fragment length polymorphism (RFLP) appears to be limited. Some V Tβ gene families, however, are missing from Rattus (VTβ7, V Tβ12) and M. shortridgei (V Tβ9, V Tβ16). Extension of the V Tβ survey to a panel of 38 wild-caught mice reveals that nearly a third lack specific hybridization to the V Tβ5 probe. Previous reports have established that the mouse inbred strains SJL, C57BR, C57L, and SWR lack 50% of their V Tβ repertoire, including V Tβ5 (Behlke et al. 1985). This study demonstrates that natural populations of mice also carry a significantly reduced V Tβ gene repertoire.Keywords
This publication has 33 references indexed in Scilit:
- Human T cell receptor V beta gene polymorphism.The Journal of Experimental Medicine, 1987
- T-Cell Receptor β-Chain Expression: Dependence on Relatively Few Variable Region GenesScience, 1985
- The murine T-cell receptor uses a limited repertoire of expressed Vβ gene segmentsNature, 1985
- A third rearranged and expressed gene in a clone of cytotoxic T lymphocytesNature, 1984
- Genomic organization and sequence of T-cell receptor β-chain constant- and joining-region genesNature, 1984
- The immunoglobulin heavy chain variable region (Igh‐V) locus in the mouse. I. One hundred Igh‐V genes comprise seven families of homologous genesEuropean Journal of Immunology, 1984
- The mouse T cell receptor: Structural heterogeneity of molecules of normal T cells defined by XenoantiserumCell, 1983
- The human T cell receptor: Appearance in ontogeny and biochemical relationship of α and β subunits on IL-2 dependent clones and T cell tumorsCell, 1983
- H-2 compatability requirement for T-cell-mediated lysis of target cells infected with lymphocytic choriomeningitis virus. Different cytotoxic T-cell specificities are associated with structures coded for in H-2K or H-2D;.The Journal of Experimental Medicine, 1975
- Cell-mediated lympholysis of trinitrophenyl-modified autologous lymphocytes. Effector cell specificity to modified cell surface components controlled by H-2K and H-2D serological regions of the murine major histocompatibility complex.The Journal of Experimental Medicine, 1975