Effect of Ouabain on Acid Secretion and Electrolyte Content of Frog Gastric Mucosa.

Abstract

Ouabain in concentrations from 10^-3 to 10^-6 M inhibits acid secretion by frog gastric mucosas in vitro and at 10^-4 M causes tissue Na to rise and K to fall. Increasing K concentration in the medium from 9 to 29 mM largely abolishes the inhibitory effect of 10^-4 M ouabain. We conclude that at least some of the inhibitory effect is the result of alteration of intracellular electrolyte pattern.