Isolation and identification of a fluorophore from ampicillin degradation
- 1 September 1979
- journal article
- research article
- Published by Oxford University Press (OUP) in Journal of Pharmacy and Pharmacology
- Vol. 31 (1), 441-443
- https://doi.org/10.1111/j.2042-7158.1979.tb13549.x
Abstract
A fluorescent impurity in ampicillin has been isolated and identified as 2-hydroxy-3-phenyl-pyrazine. The product is formed under acidic conditions similar to those employed in some fluorometric assay procedures. The mechanism of the reaction is proposed to involve cyclization by condensation of the penilloaldehyde of ampicillin. The structure was confirmed by independent synthesis.This publication has 18 references indexed in Scilit:
- Isolation and identification of the fluorescent degradation product of some β-lactam antibioticsJournal of Pharmacy and Pharmacology, 1978
- Fluorimetric determination of ampicillin and epicillinJournal of Antimicrobial Chemotherapy, 1977
- Fluorimetric assay of cephradine, cephalexin and cephaloglycin.British Journal of Clinical Pharmacology, 1977
- Cephalosporin degradationsJournal of Medicinal Chemistry, 1977
- Hydrolysis of 3-cloro-3-cephems. Intramolecular nucleophilic attack in cefaclorJournal of Medicinal Chemistry, 1977
- A simple, rapid fluorimetric assay of amoxycillin in plasmaClinica Chimica Acta; International Journal of Clinical Chemistry, 1977
- Fluorimetric determination of cephalexinJournal of Pharmacy and Pharmacology, 1976
- Alkaline Degradation Product of CephradineJournal of Pharmaceutical Sciences, 1973
- Intramolecular nucleophilic attack in 7α-aminophenylacetamido-cephalosporin estersJournal of the Chemical Society, Chemical Communications, 1972
- Kinetics and Mechanism of Degradation of Ampicillin in SolutionJournal of Pharmaceutical Sciences, 1969