Isolation and identification of a fluorophore from ampicillin degradation
- 31 August 1979
- journal article
- research article
- Published by Oxford University Press (OUP) in Journal of Pharmacy and Pharmacology
- Vol. 31 (1), 441-443
- https://doi.org/10.1111/j.2042-7158.1979.tb13549.x
Abstract
A fluorescent impurity in ampicillin has been isolated and identified as 2-hydroxy-3-phenyl-pyrazine. The product is formed under acidic conditions similar to those employed in some fluorometric assay procedures. The mechanism of the reaction is proposed to involve cyclization by condensation of the penilloaldehyde of ampicillin. The structure was confirmed by independent synthesis.This publication has 18 references indexed in Scilit:
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