Neonatal Thrombocytopenia Associated with Ante-Partum Administration of Thiazide Drugs

Abstract

WITHIN the last several years there have been scattered reports of purpura occurring in patients receiving chlorothiazide and hydrochlorothiazide.^{1 2 3 4 5 6 7} Since the conditions for which these drugs are used occur chiefly in the older age groups, purpura in association with the administration of the drugs mentioned above has not been reported in the pediatric literature.Recently, we observed a group of newborn infants with thrombocytopenia whose mothers had neither a platelet deficiency nor detectable anti-platelet antibody in the serum. However, these mothers had received either chlorothiazide, hydrochlorothiazide or methyclothiazide during pregnancy, and the thrombocytopenia in their infants was possibly due to . . .