Direct determination of volume- and time-dependence of alveolar surface tension in excised lungs.
- 1 July 1978
- journal article
- research article
- Published by Proceedings of the National Academy of Sciences in Proceedings of the National Academy of Sciences
- Vol. 75 (7), 3417-3421
- https://doi.org/10.1073/pnas.75.7.3417
Abstract
Alveolar surface tension was measured by observing the spreading properties of fluid droplets placed by micropipette within individual alveoli. Alveolar surface tension in excised rat lungs at total lung capacity and 37.degree. C was 29.7 .+-. 1.4 mN .cntdot. m-1. In lungs held at functional residual capacity, surface tension changed slowly, rising to 9 mN .cntdot. m-1 at 30 min with a subsequent, approximate linear rise to 16 mN .cntdot. m-1 at 115 min. Thereafter it rose more rapidly (20 mN .cntdot. m-1 at 140 min), suggesting that it was not asymptotically approaching an equilibrium value.This publication has 17 references indexed in Scilit:
- Direct determination of surface tension in the lung.Proceedings of the National Academy of Sciences, 1976
- Pulmonary surfactant: A surface chemistry viewpointAnnals of Biomedical Engineering, 1975
- Lung surfactantBiochimica et Biophysica Acta (BBA) - Reviews on Biomembranes, 1974
- Pressure-volume curves of air- and liquid-filled excised lungs-surface tension in situ.Journal of Applied Physiology, 1970
- Pulmonary Surfactant in Health and DiseaseDiseases of the Chest, 1965
- Effect of volume and volume history of the lungs on pulmonary shunt flowAmerican Journal of Physiology-Legacy Content, 1964
- Surface phenomena in relation to pulmonary function.1962
- Surface Properties in Relation to Atelectasis and Hyaline Membrane DiseaseArchives of Pediatrics & Adolescent Medicine, 1959
- Surface Tension of Lung ExtractsExperimental Biology and Medicine, 1957
- Properties, Function and Origin of the Alveolar Lining LayerNature, 1955