The sequence specificity of a mammalian DNA methylase
- 1 January 1977
- journal article
- Published by Oxford University Press (OUP) in Nucleic Acids Research
- Vol. 4 (4), 1039-1045
- https://doi.org/10.1093/nar/4.4.1039
Abstract
The sequence specificity of an extensively purified DNA methylase preparation from Krebs II mouse ascites cells has been examined. The enzyme appears to be highly sequence dependent. Moreover the sequence distribution of cytosine residues that are methylated, bears a very close resemblance to the sequence distribution of 5'-methyl cytosine found in vivo in a wide range of vertebrate cells and is consistent with methylation of cytosines in the sequence R-Yn-C-R.Keywords
This publication has 12 references indexed in Scilit:
- The sequence specificity of vertebrate DNA methylationNucleic Acids Research, 1977
- Doublet frequency analysis of fractionated vertebrate nuclear DNAJournal of Molecular Biology, 1976
- DNA methylase from HeLa cell nucleiNucleic Acids Research, 1975
- DNA Modification and RestrictionProgress in Nucleic Acid Research and Molecular Biology, 1974
- The mechanism of action of rat liver DNA methylase: III. Nucleotide requirements for binding and methylationBiochimica et Biophysica Acta (BBA) - Nucleic Acids and Protein Synthesis, 1972
- Mechanism of action of rat liver DNA methylase: II. Interaction with single-stranded methyl-acceptor DNAJournal of Molecular Biology, 1971
- Methylation of mammalian deoxyribonucleic acid. II. The distribution of 5-methylcytosine in pyrimidine deoxyribonucleotide clusters in Novikoff hepatoma cell deoxyribonucleic acid.1971
- Mechanism of action of rat liver DNA methylase: I. interaction with double-stranded methyl-acceptor DNAJournal of Molecular Biology, 1971
- The preparation of soluble DNA methylase from normal and regenerating rat liver.1971
- Distribution of 5-methylcytosine in pyrimidine sequences of deoxyribonucleic acidsBiochimica et Biophysica Acta, 1962