SPECIAL REPORT Endothelium‐dependent relaxation to the B1 kinin receptor agonist des‐Arg ‐bradykinin in human coronary arteries
Open Access
- 1 December 1995
- journal article
- Published by Wiley in British Journal of Pharmacology
- Vol. 116 (8), 3083-3085
- https://doi.org/10.1111/j.1476-5381.1995.tb15108.x
Abstract
Des-Arg9-bradykinin (des-Arg9-BK) caused endothelium-dependent relaxations in human, isolated coronary arteries which upregulated with in vitro incubation time. Relaxations to des-Arg9-BK were inhibited by the B1 receptor antagonist, des-Arg9-[Leu8]-BK (pKB, 6.14 ± 0.11) but were unaffected by the B2 receptor antagonist, Hoe-140. Therefore, this is the first demonstration that human coronary arteries possess endothelial B1 receptors which mediate endothelium-dependent relaxation and appear to be synthesized de novo during the incubation period.Keywords
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